Lianghui Zhang, MD, PhD

  • Assistant Professor
  • Pulmonary, Allergy and Critical Care Medicine

Education & Training

  • MD, Medical School of Fudan University, Shanghai, China, 2003
  • PhD; Pharmacology, University of Rochester, NY, 2013

Representative Publications

  • Zhang L*, Narayanan KK, Cooper L, Chan KK, Devlin CA, Aguhob A, Shirley K, Rong L*, Rehman J*, Malik AB*, Procko E*. An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2. EMBO Molecular Medicine. 2022 Sep 12:e16109.
    *: Co-corresponding authorship

  • Zhang L*, Gao S, White Z, Dai Y, Malik AB, Rehman J*. Single-Cell Transcriptomic Profiling Identifies Dynamic Inflammatory and Regenerative Subpopulations Following Vascular Injury. JCI Insight 2022 Jun 8;7(11):e158079.
    *: Co-corresponding authorship

  • Zhang L*, Dutta S, Xiong S, Chan M, Chan KK, Fan TM, Bailey KL, Lindeblad M, Cooper LM, Rong L, Gugliuzza AF, Shukla D, Procko E*, Rehman J*, Malik AB*. An engineered high affinity ACE2 peptide therapeutically mitigates lung vascular injury and mortality induced by distinct SARS-CoV-2 variants. Nature Chemical Biology, 2022 Mar;18(3):342-351.
      *: Co-corresponding authorship

  • Zhang L, Jambusaria A, Hong Z, Marsboom G, Toth PT, Herbert BS, Malik AB, Rehman J. SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34+ Progenitor Cells. Circulation. 2017 Jun 20;135(25):2505-2523.

  • Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV. Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. 2013 Mar 28;153(1):216-27.

Research Interests

My laboratory studies lung vascular biology and immuno-pathogenesis of acute lung injury. Our research focuses on the mechanism of respiratory virus-induced lung vascular injury and signals between endothelial cells and immune cells during the innate and adaptive immune response. The SARS-CoV-2 and H1N1-induced acute lung injury models are two major animal models used in the laboratory. We are also interested in lung vascular regeneration and mechanisms of transcriptional regulation in the vasculature. By understanding the mechanisms which regulate the balance between inflammatory injury and regeneration in viral lung injury, we will be able to develop new therapies that minimize inflammatory injury, maximize tissue repair and reduce patient mortality.