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Elodie Ghedin, PhD
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Associate Professor
Computational & Systems Biology
9043 BST3
3501 Fifth Avenue
Pittsburgh, Pennsylvania 15261
PubMed Publications
Phone: (412) 383-5850
Fax: (412) 383-5851
E-mail: elg21@pitt.edu
Webpage: http://www.cvr.pitt.edu/personnel/view.asp?uid=elg21
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Lab Information
Phone: (412) 383-5355
Fax:
E-mail:
Webpage: http://ghedinlab.csb.pitt.edu/GhedinLab
Lab Members:
• Cui, Lijia
• Fitch, Adam C
• Ghedin, Elodie
• Rakova, Irina
• Rogers, Matthew Brian
• Saira, Kazima
• Song, Timothy Y
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Biography
Elodie Ghedin is an Assistant Professor in the Department of Computational and Systems Biology. She earned her B.S. and Ph.D. from McGill University in Canada. She was a postdoctoral fellow at the National Institute of Allergy and Infectious Diseases (NIAID) (1998-2000) until she joined The Institute for Genomic Research where she stayed until 2006.
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Research
The underlying theme in Dr. Ghedin’s research is the genomics of infectious diseases. She has worked on the causative agents for African sleeping sickness, Chagas disease, cutaneous and visceral leishmaniases, and lymphatic filariasis. During her time at The Institute for Genomic Research (TIGR) Dr. Ghedin led the Viral Genomics group, working on the design of high throughput pipelines for virus discovery and characterization.
The research interests in Dr. Ghedin’s laboratory fall into three broad areas:
1) Influenza evolutionary dynamics – active projects: whole-genome sequencing and molecular epidemiology of influenza virus;
2) Parasite Genomics – active projects: whole genome analysis of the parasitic filarial nematode Brugia malayi; mapping of Filaria-Wolbachia interactions;
3) Human Microbiome – active project: Analysis of the microbiome associated with the pathogenesis of lung obstruction and emphysema in HIV patients.
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Selected Publications
- Lam TT, Ip HS, Ghedin E, Wentworth DE, Halpin RA, Stockwell TB, Spiro DJ, Dusek RJ, Bortner JB, Hoskins J, Bales BD, Yparraguirre DR, Holmes EC. Migratory flyway and geographical distance are barriers to the gene flow of influenza virus among North American birds. Ecol Lett. 2012 Jan;15(1):24-33. doi: 10.1111/j.1461-0248.2011.01703.x. Epub 2011 Oct 18. PMID:22008513
- Liu C, Kelen PV, Ghedin E, Lustigman S, Unnasch TR. Analysis of transcriptional regulation of tetracycline responsive genes in Brugia malayi. Mol Biochem Parasitol. 2011 Dec;180(2):106-11. Epub 2011 Sep 16.
PMID:21944995
- Bahl J, Nelson MI, Chan KH, Chen R, Vijaykrishna D, Halpin RA, Stockwell TB, Lin X, Wentworth DE, Ghedin E, Guan Y, Peiris JS, Riley S, Rambaut A, Holmes EC, Smith GJ. Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19359-64. Epub 2011 Nov 14. PMID:22084096[PubMed - in process] Free Article
- Scott AL, Ghedin E, Nutman TB, McReynolds LA, Poole CB, Slatko BE, Foster JM. Filarial and Wolbachia Genomics. Parasite Immunol. 2011 Nov 18. doi: 10.1111/j.1365-3024.2011.01344.x. PMID:22098559
- Melnikow E, Xu S, Liu J, Li L, Oksov Y, Ghedin E, Unnasch TR, Lustigman S.
Interaction of a Wolbachia WSP-like protein with a nuclear-encoded protein of Brugia malayi. Int J Parasitol. 2011 Aug 15;41(10):1053-61. Epub 2011 Jul 6. PMID:21782817
- Dwyer DE; INSIGHT Influenza Study Group. Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: the INSIGHT FLU 002 and FLU 003 studies. Vaccine. 2011 Jul 22;29 Suppl 2:B56-62. PMID:21757105
- Ping J, Keleta L, Forbes NE, Dankar S, Stecho W, Tyler S, Zhou Y, Babiuk L, Weingartl H, Halpin RA, Boyne A, Bera J, Hostetler J, Fedorova NB, Proudfoot K, Katzel DA, Stockwell TB, Ghedin E, Spiro DJ, Brown EG. Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse. PLoS One. 2011;6(6):e21740. Epub 2011 Jun 30. PMID:21738783[PubMed - in process] Free PMC Article
- Bennuru S, Meng Z, Ribeiro JM, Semnani RT, Ghedin E, Chan K, Lucas DA, Veenstra TD, Nutman TB. Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia.
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9649-54. Epub 2011 May 23.
PMID:21606368[PubMed - indexed for MEDLINE] Free PMC Article
- Holmes EC, Ghedin E, Halpin RA, Stockwell TB, Zhang XQ, Fleming R, Davey R, Benson CA, Mehta S, Taplitz R, Liu YT, Brouwer KC, Wentworth DE, Lin X, Schooley RT; INSIGHT FLU002 Study Group. Extensive geographical mixing of 2009 human H1N1 influenza A virus in a single university community.
J Virol. 2011 Jul;85(14):6923-9. Epub 2011 May 18. PMID:21593168
- Vlasova AN, Halpin R, Wang S, Ghedin E, Spiro DJ, Saif LJ. Molecular characterization of a new species in the genus Alphacoronavirus associated with mink epizootic catarrhal gastroenteritis. J Gen Virol. 2011 Jun;92(Pt 6):1369-79. Epub 2011 Feb 23. PMID:21346029
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