Todd A. Reinhart, ScD

Todd Reinhart Professor
Infectious Diseases & Microbiology
606 Parran Hall
130 Desota Street
Pittsburgh, Pennsylvania 15261


Phone: (412) 648-2341
Fax: (412) 624-4873
E-mail: reinhar@pitt.edu
Webpage: http://www.cvr.pitt.edu/personnel/view.asp?uid=reinhar
Research

      Role of chemokines in the pathogenesis of HIV-1 and SIV; basic biology and inhibition of chemokines; roles played by lymphatic endothelial cells in infectious diseases and vaccines; vaccines for HIV-1, influenza, and cancer.

Selected Publications

  • Pegu, A, S Qin, BA Fallert Junecko, RE Nisato, MS Pepper, and TA Reinhart. (2008) Human Lymphatic Endothelial Cells Express Multiple Functional Toll-like Receptors. Journal of Immunology 180(5):3399-3405.


  • Aujla, SJ, M Fei, DA Pociask, TA Reinhart, J Edeal, K Gaus, JL Kreindler, PJ Dubin, M Zheng, JM Pilewski, MM Myerburg, CA Mason, Y Iwakura, and J Kolls. (2008) IL-22 Mediates Mucosal Host Defense against Gram Negative Bacterial Pneumonia. Nature Medicine 14(3):275-81.


  • Qin, S, Y Sui, A Soloff, BAF Junecko, SC Watkins, DE Kirschner, JE Pease, MA Murphey-Corb, S Barratt-Boyes, and TA Reinhart. (2008) Chemokine and Cytokine Mediated Loss of Regulatory T cells in Lymphoid Tissues during Pathogenic Simian Immunodeficiency Virus Infection. †These authors contributed equally to this work. Journal of Immunology 180:5530-5536.


  • Qin, S, BA Fallert Junecko, AM Trichel, PM Tarwater, MA Murphey-Corb, DE Kirschner, and TA Reinhart. (2010) Simian Immunodeficiency Virus Infection Alters Chemokine Networks in Lung Tissues of Cynomolgus Macaques: Association with Pneumocystis carinii infection. American Journal of Pathology 177(3):1274-85.


  • Muthuswamy, R, J Mueller-Berghaus, W Mier, U Haberkorn, TA Reinhart, D Schadendorf, and P Kalinski. (2010) PGE2 Transiently Enhances DC Expression of CCR7 but Inhibits the Ability of DCs to Produce CCL19 and Attract Naïve T cells. Blood 116(9):1454-9.


  • Okada, H, P Kalinski, R Ueda, A Hoji, G Kohanbash, TE Donegan, AH Mintz, JA Engh, DL Bartlett, CK Brown, H Zeh, MP Holtzman, TA Reinhart, TL Whiteside, LH Butterfield, RL Hamilton, D Potter, IF Pollack, AM Salazar, and FS Lieberman. (2011) Induction of CD8+ T cell Responses against Novel Glioma-Associated Antigen Peptides and Clinical Activity by Vaccinations with alpha-Type-1-Polarized Dendritic Cells and Poly-ICLC in Patients with Recurrent Malignant Glioma. Journal of Clinical Oncology 29:330-36.


  • Qin, S, JF Alcorn, JK Craigo, C Tjoeng, Patrick M Tarwater, JK Kolls, and TA Reinhart. (2011) Epigallocatechin-3-Gallate Reduces Airway Inflammation in Mice through Binding to Proinflammatory Chemokines and Inhibiting Inflammatory Cell Recruitment. Journal of Immunology 186(6):3693-700.


  • Fei, M, S Bhatia, TB Oriss, M Yarlagadda, A Khare, S Akira, S Saijo, Y Iwakura, BA Fallert-Junecko, TA Reinhart, O Foreman, P Ray, JK Kolls, A Ray. (2011) TNF-α From Inflammatory DCs Regulates IL-17A Levels Which Together Determines Neutrophilic Lung Inflammation During Persistent Fungal Infection. Proceedings of the National Academy of Sciences (USA) 108(13):5360-5.





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