Karen A. Norris, PhD

Karen Norris Professor
200 Lothrop Street
Pittsburgh, Pennsylvania 15261

  FRIP Database
  PubMed Publications

Phone: (412) 648-8848
Fax: (412) 383-8098
E-mail: kan1@pitt.edu
Webpage: http://immunology.medicine.pitt.edu/person/karen-norris-phd

      Dr. Norris conducts research in immunology and infectious diseases with emphasis on vaccine development, co-morbidities and opportunistic infections associated with HIV infection, chronic immune activation and aging. She has developed a team of investigators and collaborators who provide expertise in all aspects of these studies including veterinary, pulmonary, cardiology, pathology, immunology, radiology, virology and immunology. This team has been successful in establishing the first primate model of Pneumocystis pneumonia, chronic obstructive pulmonary disease (COPD) and pulmonary arterial hypertension. Current studies are underway to test the efficacy of Pneumocystis vaccine in pre-clinical models and develop therapeutic interventions to treat inflammation-mediated diseases including diabetes, pulmonary hypertension and COPD.

Selected Publications

  • Fitzpatrick ME, Tedrow JR, Hillenbrand ME, Lucht L, Richards T, Norris KA, Zhang Y, Sciurba FC, Kaminski N, Morris A. Microbiol Immunol. 2014 Pneumocystis jirovecii colonization is associated with enhanced Th1 inflammatory gene expression in lungs of humans with chronic obstructive pulmonary disease. 58(3):202-11.PMID: 24438206

  • Kling HM, Shipley TW, Guyach S, Tarantelli R, Morris A, Norris KA. 2014. Trimethoprim-sulfamethoxazole treatment does not reverse obstructive pulmonary changes in pneumocystis-colonized nonhuman primates with SHIV infection. J Acquir Immune Defic Syndr. 2014. Apr 1;65(4):381-9. PMID: 24121760

  • George MP, Champion HC, Simon M, Guyach S, Tarantelli R, Kling HM, Brower A, Janssen C, Murphy J, Carney JP, Morris A, Gladwin MT, Norris KA. 2013. Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension. Am J Respir Cell Mol Biol. Mar;48(3):374-81. PMID: 23239493

  • Bryan M, Guyach S, Norris KA. 2013. Biolistic DNA vaccination against Trypanosoma infection. Methods Mol Biol. 940:305-15. PMID: 23104351

  • Morris A, Hillenbrand M, Finkelman M, George MP, Singh V, Kessinger C, Lucht L, Busch M, McMahon D, Weinman R, Steele C, Norris KA, Gingo MR. 2012. Serum (1→3)-β-D-glucan levels in HIV-infected individuals are associated with immunosuppression, inflammation, and cardiopulmonary function. J Acquir Immune Defic Syndr. 2012 Dec 1;61(4):462-8. PMID: 22972021

  • George MP, Champion HC, Gladwin MT, Norris KA, Morris A.Injection drug use as a "second hit" in the pathogenesis of HIV-associated pulmonary hypertension. 2012. Am J Respir Crit Care Med. 2012 Jun 1;185(11):1144-6. PMID: 22661521

  • Morris A, Norris KA. 2012. Colonization by Pneumocystis jirovecii and its role in disease. Clin Microbiol Rev. Apr;25(2):297-317. PMID: 22491773

  • Morris A, Gingo MR, George MP, Lucht L, Kessinger C, Singh V, Hillenbrand M, Busch M, McMahon D, Norris KA, Champion HC, Gladwin MT, Zhang Y, Steele C, Sciurba FC. 2012. Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy era. AIDS. 2012 Mar 27;26(6):731-40. PMID: 22210636

  • Sivam S, Sciurba FC, Lucht LA, Zhang Y, Duncan SR, Norris KA, Morris A.Distribution of Pneumocystis jirovecii in lungs from colonized COPD patients. Diagn Microbiol Infect Dis. 2011 Sep;71(1):24-8. PMID: 21851870

  • Kling HM, Shipley TW, Norris KA.. 2011. Alterations in peripheral blood B-cell populations in SHIV89.6P-infected macaques (Macacca fascicularis). Comp Med. 61(3):269-77.PMID: 21819698

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