Joanne Flynn, PhD

Joanne Flynn Professor
Microbiology & Molecular Genetics
W1157 BSTWR
200 Lothrop Street
Pittsburgh, Pennsylvania 15261

  PubMed Publications

Phone: (412) 624-7743
Fax:
E-mail: joanne@pitt.edu
Webpage: http://www.cvr.pitt.edu/personnel/view.asp?uid=joanne
Biography

      EDUCATION AND TRAINING UNDERGRADUATE 9/78-6/82 University of California, Davis B.S. 1982 Biochemistry Department of Biochemistry cum laude Davis, CA GRADUATE 9/82-987 University of California, Berkeley Ph. D. 1987 Microbial Genetics/ Department of Microbiology and Pathogenic Mechanisms Immunology Berkeley, CA Advisor: Dennis E. Ohman, Ph. D. POST-GRADUATE Post-doctoral fellow 10/87-6/90 Research Institute of Scripps Clinic Microbial Genetics/ Department of Molecular Biology Vaccine Development La Jolla, CA Advisor: Magdalene So, Ph. D. Research Associate Howard Hughes Medical Institute Immunology/Microbial 6/90-12/93 Albert Einstein College of Medicine Pathogenesis Bronx, NY Advisor: Barry R. Bloom, Ph. D.

Research

      Mycobacterium tuberculosis pathogenesis and immunology

Selected Publications

  • Gideon HP, Flynn JL. Latent tuberculosis: what the host "sees"? Immunol Res. 2011 Jun 30. [Epub ahead of print]PMID:21717066


  • Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, Mohaideen N, Ioerger TR, Sacchettini JC, Lipsitch M, Flynn JL, Fortune SM. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nat Genet. 2011 May;43(5):482-6. Epub 2011 Apr 24. PMID:21516081


  • Flynn JL, Chan J, Lin PL. Macrophages and control of granulomatous inflammation in tuberculosis. Mucosal Immunol. 2011 May;4(3):271-8. Epub 2011 Mar 23. PMID:21430653


  • Diedrich CR, Flynn JL. HIV-1/mycobacterium tuberculosis coinfection immunology: how does HIV-1 exacerbate tuberculosis? Infect Immun. 2011 Apr;79(4):1407-17. Epub 2011 Jan 18. Review. PMID:21245275


  • Mattila JT, Diedrich CR, Lin PL, Phuah J, Flynn JL. Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation. J Immunol. 2011 Mar 15;186(6):3527-37. Epub 2011 Feb 11. PMID:21317393


  • Kirschner DE, Young D, Flynn JL. Tuberculosis: global approaches to a global disease. Curr Opin Biotechnol. 2010 Aug;21(4):524-31. Epub 2010 Jul 14. Review. PMID:20637596


  • Green AM, Mattila JT, Bigbee CL, Bongers KS, Lin PL, Flynn JL. CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection. J Infect Dis. 2010 Aug 15;202(4):533-41. PMID:20617900


  • Marino S, Myers A, Flynn JL, Kirschner DE. TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: a next-generation two-compartmental model. J Theor Biol. 2010 Aug 21;265(4):586-98. Epub 2010 May 25.PMID:20510249


  • Lin PL, Flynn JL. Understanding latent tuberculosis: a moving target. J Immunol. 2010 Jul 1;185(1):15-22. Review. PMID:20562268


  • Russell DG, Barry CE 3rd, Flynn JL. Tuberculosis: what we don't know can, and does, hurt us. Science. 2010 May 14;328(5980):852-6. Review. PMID:20466922





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