Eduardo Nascimento, PhD

Eduardo Nascimento Research Assistant Professor
Center for Vaccine Research (CVR)
9052 BST3
3501 Fifth Avenue
Pittsburgh, Pennsylvania 15261

  Curriculum Vitae
  Google Scholar

Phone: (412) 624-3804
Fax: (412) 624-4440

      Dengue virus (DENV) is a major public health concern worldwide. DENV has four serotypes that mostly causes asymptomatic to a mild clinical manifestation called dengue fever (DF). However, some subjects exposed to the virus suffer a more severe form of the disease, referred as dengue hemorrhagic fever (DHF), characterized by vasculopathy that may be fatal if not treated promptly. Correlates of DHF include, but not limited, to antibody responses and complement activation. My research has been focused on identifying potential correlates of dengue severity based on antibody responses and complement activation using clinical samples from confirmed dengue cases. These correlates can be used for development of targets for therapeutics and prophylactics against DHF.

Selected Publications

  • Ole Lund, Eduardo J. M. Nascimento, Milton Maciel, Jr, Morten Nielsen, Mette Voldby Larsen, Claus Lundegaard, Mikkel Harndahl, Kasper Lamberth, Søren Buus, Jérôme Salmon, Thomas J. August, and Ernesto T. A. Marques, Jr. Human Leukocyte Antigen (HLA) Class I Restricted Epitope Discovery in Yellow Fewer and Dengue Viruses: Importance of HLA Binding Strength. PLoS One, v.6(11); 2011.

  • Nascimento, E.J.M.; Braga-Neto, U ; Calzavara, C.; Gomes, A. L.; Abath, F; Acioli, B; Brito, C.A.A.; Cordeiro, M.; Silva, A.; Magalhaes, C; Andrade, R; Gil, L.; Marques Jr, E.T.A. Gene expression profiling during acute stage of dengue infection can predict patient outcome. PLoS One, vol. 4 (11) pp. e7892, 2009.

  • Eduardo J. M. Nascimento, Ana M. Silva, Marli T. Cordeiro, Carlos A. A. Brito, Laura H. V. G. Gil, Ulisses Braga-Neto and Ernesto T. A. Marques Jr. Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity. PLoS One 4:e6782, 2009.

  • Andréa N. M. Rangel da Silva, Eduardo J. M. Nascimento, Marli Tenório Cordeiro, Frederico G.C. Abath, Silvia M.L. Montenegro, Ernesto T. A. Marques Junior. Identification of Continuous B-cell Epitopes in the Glycoprotein Envelope of Dengue Virus Type 3 (DENV-3). PLoS One, vol. 4 (10) pp. e7425, 2009.

  • Asif M. Khan, Olivo Miotto, Eduardo J. M. Nascimento, J. Salmon, K.N. Srinivasan, A.T. Heiny, Guang Lan Zhang, E.T. Marques, Tin Wee Tan, Vladimir Brusic, J. Thomas August. Conservation and Variability of Dengue Virus Proteins: Implications for Vaccine Design PLoS Negl Trop Dis 2(8): e272, 2008.

  • Marli Tenório Cordeiro, Ana Maria Silva, Carlos A A Brito, Eduardo J M Nascimento, Maria Cecilia F Magalhães, Georgia F Guimarães, Norma Lucena-Silva, Eduardo Freese de Carvalho, Ernesto T A Marques, Jr. Characterization Of A Dengue Patient Cohort In Recife, Brazil. Am J Trop Med Hyg, 77(6): 1128-1134, 2007.

  • Asif M. Khan, Olivo Miotto, A.T. Heiny, Jerome Salmon, K.N. Srinivasan, Eduardo J M Nascimento, Ernesto T. Marques, Vladimir Brusic, Tin Wee Tan, J. Thomas August. A systematic bioinformatics approach for selection of epitope-based vaccine targets. Cellular Immunology, 244: 141-7, 2006.

  • Nascimento E.J.M, Amorim RV, Cavalcanti A, Alves VF, Nakazawa M, Pereira VR, Lucena-Silva N. Assessment of a DNA vaccine encoding an anchored-glycosylphosphatidylinositol tegumental antigen complexed to protamine sulphate on immunoprotection against murine schistosomiasis. Mem Inst Oswaldo Cruz,102(1):21-7, 2007.

  • Nascimento E, Pereira VRA, Gomes YM, Chikhlicar P, August A, Marques E, Lucena-Silva N. Protective immunity of single and multi-antigen DNA vaccines against schistosomiasis. Memórias do Instituto Oswaldo Cruz, 97 (suppl. I): 105-109, 2002

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