Ronald C. Montelaro, PhD

Ronald Montelaro Co-Director, CVR
Professor

Microbiology & Molecular Genetics
9016 BST3
3501 Fifth Avenue
Pittsburgh, Pennsylvania 15261

  FRIP Database
  PubMed Publications

Phone: (412) 648-8869
Fax: (412) 624-4440
E-mail: rmont@cvr.pitt.edu
Webpage: http://www.cvr.pitt.edu/personnel/view.asp?uid=rmont




Research

      The primary focus of the Montelaro lab is to elucidate the intricate interactions between viral pathogens and host immune responses to determine the mechanisms by with host immunity contributes to protection and disease and to serve as a basis for the development of effective vaccines. A particular interest of the lab is to develop effective strategies to overcome the challenge of natural viral antigenic variation that has evolved as a common complication to the development of effective vaccines to important viral diseases, including those related to biodefense and emerging infectious diseases. Systems currently under investigation include HIV-1 and related animal lentiviruses (SHIV, SIV, and EIAV), dengue virus, and influenza virus. Studies in these systems include investigation of the nature and role of antigenic variation during infection, the development of novel assays to characterize virus-specific innate, humoral, and cellular immune responses, and the design of engineered immunogens for effective vaccination against variant strains of a particular virus. In addition to these vaccine related studies, the lab also maintains a research program to develop novel de novo antimicrobial peptides (engineered cationic amphipathic peptides, or eCAPs) that can be used to inactivate a diverse spectrum of bacteria or enveloped viruses in a prophylactic or therapeutic treatment modalities.

Selected Publications

  • Steckbeck, J., Sun, C., Sturgeon, T., and Montelaro, R. (2013) Detailed topology mapping reveals substantial exposure of the “cytoplasmic” C-terminal tail (CTT) sequences in the HIV-1 Env protein at the cell surface. PLoS One 8(5):e65220


  • Paranjape, S., Lauer, T., Montelaro, R., and Mietzner, T. (2013) Modulation of proinflammatory activity by the engineered cationic antimicrobial peptide WLBU-2. F1000Research 2:36 (doi:10.34 10/f1000research.2-36.v1)


  • Deslouches, B., Steckbeck, J., Craigo, J., Doi, Y., Mietzner, T., and Montelaro, R. (2013) Rational design of engineered antimicrobial peptides consisting exclusively of arginine and tryptophan: WR eCAP activity against multi-drug resistant pathogens. Antimicrobial Agents and Chemotherapy 57: 2511-2521.


  • Craigo, J., Ezzelarab, C., Cook, S., Chong, L., Horohov, D., Issel, C., and Montelaro, R. (2013) Envelope determinants of equine lentiviral vaccine protection. PLoS One 8(6):e66093.


  • Boscia, A., Akabori, K., Benamram, Z., Michel, J., Jablin, M., Steckbeck, J., Montelaro, R., Nagle, J., and Tristram-Nagle, S. (2013) Membrane structure correlates to function of LLP2 on the cytoplasmic tail of HIV-1 gp41 protein. Biophysical J. 105: 657-666.


  • Yang, Y. Kulka, K., Montelaro, R., Reinhart, T., Sisson, J., Aderem, A., and Ojha, A. (2014) A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis. Cell Host & Microbe 15: 153-163.


  • Kuhlmann, A., Steckbeck, J., Sturgeon, T., Craigo, J., and Montelaro, R. (2014) Unique functional properties of conserved arginine residues in the lentivirus lytic peptide domains of the C-terminal tail of HIV-1 gp41. J. Biol. Chem. 289: 7630-7640.


  • Steckbeck, J., Deslouches, B., and Montlelaro, R. (2013) Antimicrobial peptides: New drugs for bad bugs? Exp. Opinion Biol. Therap. 14: 10.1517/14712598.2013.844227


  • Craigo, J. and Montelaro, R. (2013) Lessons in AIDS vaccine development learned from studies of equine infectious anemia virus infection and disease. Viruses 5: 2963-2976.


  • Steckbeck, J., Kuhlmann, AS, and Montelaro, R. (2014) Structural and functional comparisons of retroviral envelope protein C-terminal domain: still much to learn. Viruses 6: 284-300. PMC3917443


Lab Information

Phone: (412) 648-8874
Fax: (412) 624-4440
E-mail: rmont@cvr.pitt.edu
Personnel
Tricia Gearhart
Tricia L. Gearhart, PhD
Research, CVR
Postdoctoral Scholar
Center for Vaccine Research (CVR)
9028 BST3
(412) 648-8874
tlg50@cvr.pitt.edu
Mary Hasek
Mary Hasek
Infectious Disease & Microbiology Student

Center for Vaccine Research (CVR)
9026 BST3
(412) 628-8874
mlh92@cvr.pitt.edu
Anne-Sophie Kuhlmann
Anne-Sophie Kuhlmann, PhD
Research, CVR
Post-Doctoral Associate
Center for Vaccine Research (CVR)
9028 BST3
(412) 648-8874
ask181@cvr.pitt.edu
Ronald Montelaro
Ronald C. Montelaro, PhD
Member, CVR
Co-Director, CVR
Professor

Microbiology & Molecular Genetics
9016 BST3
(412) 648-8869
rmont@cvr.pitt.edu
Jonathan Steckbeck
Jonathan Damien Steckbeck, PhD, MBA
Research, CVR
Post Doctoral Associate
Center for Vaccine Research (CVR)
9026 BST3
412-648-8874
jds170 at CVR dot pitt dot edu
Timothy Sturgeon
Timothy J. Sturgeon
Research, CVR
Flow Cytometry Specialist
Center for Vaccine Research (CVR)
9028 BST3
(412) 383-5333
sturgeon@cvr.pitt.edu


Alumni

Montelaro Laboratory Alumni


Lab Photos



Interesting Links


Center for Vaccine Research
University of Pittsburgh
Pittsburgh - A New Vision
Visit Pittsburgh





Copyright © 2010 Center for Vaccine Research
Last Modified: Wednesday, February 25, 2009 at 12:15:22 AM
Disclosure Statement   •   Sitemap   •   Contact Us